Purine Analogues for Treatment of Refractory Essential Mixed Cryoglobulinemia
نویسندگان
چکیده
منابع مشابه
Essential mixed cryoglobulinemia type II.
We report a rare case of essential mixed cryoglobulinemia type II with membrano-proliferative glomerulonephritis (MPGN) type I in which HCV was not found. Long-term history of palindromic rheumatism, skin leukocytoclastic vasculitis attacks and micro-normocytic anemia preceded the appearance of cryoglobulinemia. Cryoprecipitate consisted of monoclonal IgMk-RF and polyclonal IgG (essential mixed...
متن کامل9 Renal Involvement in Essential Mixed Cryoglobulinemia
Up to the end of the 1980s, the cause of about 30% of both type II and III mixed cryoglobulinemias (MC) in patients was not known, and this subgroup of patients were referred to as having essential mixed cryoglobulinemia. Essential mixed cryoglobulinemia was characterized clinically by systemic signs, mainly purpura, arthralgias, and fever, together with hepatic, neurologic, and renal symptoms....
متن کاملTreatment of mixed cryoglobulinemia: a rheumatology perspective.
The treatment of the cryoglobulinemic syndrome or vasculitis (CV) must be targeted to the individual patient, and requires clinical expertise and knowledge of the disease biology. In general, the treatment is suggested by the clinical picture, but biologic issues should also be considered. Both immunosuppressive and antiviral approaches deserve equal attention based on the wide clinical spectru...
متن کاملBiopsy-Documented Myopathy and Vasculitis in Essential Mixed Cryoglobulinemia
A skeletal muscle involvement associated with skin, renal and liver pathology has been described in patients with essential mixed cryoglobulinemia. In some cases the muscle atrophy was consequence of a peripheral neuropathy but in such patients the muscle pathology has not been defined. Skin and skeletal muscle biopsies were performed in 6 patients with type II essential mixed cryoglobylinemia....
متن کاملMixed cryoglobulinemia
Mixed cryoglobulinemia (MC), type II and type III, refers to the presence of circulating cryoprecipitable immune complexes in the serum and manifests clinically by a classical triad of purpura, weakness and arthralgias. It is considered to be a rare disorder, but its true prevalence remains unknown. The disease is more common in Southern Europe than in Northern Europe or Northern America. The p...
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ژورنال
عنوان ژورنال: Mayo Clinic Proceedings
سال: 1997
ISSN: 0025-6196
DOI: 10.4065/72.1.92-b